From Asheville, NC
Take I-26 North towards Johnson City and get off at Exit 19A to the right under the overpass. This will put you on US 25/70 North towards Hot Springs, about 26 miles away. As you approach Hot Springs, you will see detour signs which you can ignore as the detour is beyond town entering from Tennessee. Once you cross the bridge over the French Broad River you are in Hot Springs.
Trip distance and time from Asheville, 36 miles, 45 minutes.
From Knoxville, TN
Take I-40 East towards Asheville and get off at Exit 432-B in Newport, TN to get onto US 25/70. There take US 25/70 East through downtown Newport towards Hot Springs going about 25 miles. If you turn left at the first intersection and go 100 yards the Welcome Center is on the right. The center of town is one block ahead.
Trip distance and time from Knoxville, 74 miles, 1 hour and 27 minutes.
From Johnson City, TN
Take I-26 South towards Asheville and get off at Exit 11 in Mars Hill. Take NC 213 West for 8 miles until you reach US 25/70. Once there, take US 25/70 North towards Hot Springs, about 17 miles away. Once you cross the bridge over the French Broad River you are in Hot Springs.
Trip distance from Johnson City, 68 miles, and 1 hr and 20 minutes.